Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
| ▸ | WDR5 | P61964 | 6/20 | 0.46 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.46 |
| ▸ | MTOR | P42345 | 6/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 3/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506325 | 0.89 | MAP4K1 (0.57) | MAP3K11CAMKK2MAP4K1FLT4FLT3 | |
| SCHEMBL28511344 | 0.88 | CAMKK2 (0.49) | MAP3K11CAMKK2WDR5MAP4K1IL2 | |
| SCHEMBL28502218 | 0.87 | MAP4K1 (0.54) | MAP3K11CAMKK2MAP4K1IL2PIK3CG | |
| SCHEMBL28511000 | 0.87 | MAP3K11 (0.48) | MAP3K11CAMKK2WDR5MAP4K1FLT4 | |
| SCHEMBL28906202 | 0.86 | CAMKK2 (0.54) | MAP3K11CAMKK2MAP4K1IL2PIK3CG | |
| SCHEMBL28509597 | 0.85 | MAP3K11 (0.46) | MAP3K11CAMKK2MAP4K1IL2PIK3CG | |
| SCHEMBL28513743 | 0.85 | MAP4K1 (0.60) | MAP3K11CAMKK2MAP4K1IL2 | |
| SCHEMBL28504614 | 0.84 | CAMKK2 (0.49) | MAP3K11CAMKK2MAP4K1IL2PIK3CG | |
| SCHEMBL28499626 | 0.84 | MAP4K1 (0.61) | MAP3K11CAMKK2MAP4K1IL2 | |
| SCHEMBL28514908 | 0.84 | MAP4K1 (0.58) | MAP3K11CAMKK2MAP4K1FLT4FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |