Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM3 | Q14832 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | VNN1 | O95497 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25668251 | 0.81 | CRBN (0.54) | GRM3CYP2C9CYP2D6TSHRCYP2C19 | |
| SCHEMBL951459 | 0.81 | NAMPT (0.53) | GPR183HSD17B10CYP2C9CYP3A4CYP2C19 | |
| SCHEMBL29950978 | 0.77 | HPGD (0.57) | ALDH1A1HPGDPKMPOLB | |
| SCHEMBL31037268 | 0.77 | GPR183 (0.47) | GPR183TSHRGABRDGABRA1GABRB1 | |
| SCHEMBL204078 | 0.74 | HPGD (0.70) | USP2TSHRALDH1A1HPGD | |
| SCHEMBL950365 | 0.74 | HPGD (0.64) | HSD17B10TSHRALDH1A1HPGDPOLB | |
| SCHEMBL15758020 | 0.73 | GPR183 (0.44) | GPR183TSHRALDH1A1HPGDPKM | |
| SCHEMBL532147 | 0.73 | POLB (0.65) | CYP2C9CYP2D6TSHRCYP2C19HPGD | |
| SCHEMBL15473398 | 0.73 | GABRD (0.63) | GRM3GABRDGABRA1GABRB1GABRA5 | |
| SCHEMBL28502409 | 0.73 | GPR183 (0.46) | GPR183HSD17B10CYP2C9CYP2D6USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |