GABRD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL15406	0.61	20/20
Fipronil (SCHEMBL15088)	0.59	20/20
SCHEMBL41972	0.59	20/20
Fipronil (SCHEMBL44222)	0.59	20/20
Ethiprole (SCHEMBL27048)	0.56	20/20
SCHEMBL25897	0.51	20/20
SCHEMBL33214	0.52	19/20
SCHEMBL26584	0.51	19/20
SCHEMBL9107	0.56	12/20
SCHEMBL8532	1.00	11/20
SCHEMBL9035	0.56	10/20
SCHEMBL8632	0.54	10/20
SCHEMBL8670	0.57	9/20
SCHEMBL8856	0.53	9/20
SCHEMBL9273	0.53	9/20
SCHEMBL8931	0.51	9/20
SCHEMBL8932	0.51	9/20
SCHEMBL9163	0.58	8/20
SCHEMBL8941	0.54	8/20
SCHEMBL8047	0.56	7/20

Clinical trials — most relevant to GABRD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Computational Assessment of GABA Receptor Modulation in PTSD	PHASE4	RECRUITING
Safety of Ramelteon in Elderly Subjects	PHASE4	COMPLETED
Continuous Oral Contraceptive Treatment in Premenstrual Dysphoric Disorder (PMDD)	PHASE4	COMPLETED
Bispectral Index-guided Sedation for Flexible Bronchoscopy	PHASE4	COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia	PHASE3	COMPLETED
Efficacy and Safety Study of Lamotrigine to Treat Trigeminal Neuralgia	PHASE2/PHASE3	COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia	PHASE2	COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia	PHASE2	COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy	PHASE1/PHASE2	WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome	PHASE2	RECRUITING
Effects of Direct Transcranial Current Stimulation on Central Neural Pain Processing in Fibromyalgia	PHASE1/PHASE2	COMPLETED
Physiologic Effects of Topiramate on Cognition	PHASE1	COMPLETED
Neurosteroids and Acute Alcohol Intoxication in Humans	PHASE1	UNKNOWN
MEG Study of Acute STX209 Effects in ASD	EARLY_PHASE1	COMPLETED
Synaptic Mechanisms of Continuous Theta Burst Stimulation in Depression	EARLY_PHASE1	RECRUITING
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T	EARLY_PHASE1	UNKNOWN
GABA Biomarkers in Dravet Syndrome	nan	RECRUITING
Brain Changes in Patients With Focal Hand Dystonia	nan	COMPLETED
Oral Pregabalin Premedication for Postoperative Pain Relief	nan	UNKNOWN
Potential Synergistic Effect of Combined Blood Flow Restriction Training and Betaine Supplementation on Skeletal Muscle	nan	COMPLETED
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy	nan	UNKNOWN
Pilot Study Evaluating Neuro-Imaging Correlates of Epigenetic Finding in Prediction of Chronic Postsurgical Pain	nan	UNKNOWN
Brain Chemical Receptor Effects in Patients With Panic Disorder and Post-Traumatic Stress Disorder	nan	COMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery.	nan	COMPLETED
Mechanisms of Human Plasticity in the Human System	nan	COMPLETED
Assessment of Peripheral GABA Receptors for Local Pain Relief	nan	UNKNOWN
A Positional Cloning Study on Schizophrenia	nan	COMPLETED
The Effect of Repetitive Transcranial Magnetic Stimulation (rTMS) on Working Memory	nan	COMPLETED
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Effect of Vitamin D Administration Along With SSRIs in Patients With Major Depressive Disorder	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a GABRD binder may also engage these)

Protein	Name	Similarity
P22933	—	1.000	P22933 →
P18506	—	1.000	P18506 →
GLRA1	Glycine receptor subunit alpha-1	0.992	landscape →
G5EBR3	—	0.987	G5EBR3 →
Q64018	—	0.987	Q64018 →
GLRA3	Glycine receptor subunit alpha-3	0.986	landscape →
P91730	—	0.986	P91730 →
Q8QZW7	—	0.986	Q8QZW7 →
Q91XP5	—	0.985	Q91XP5 →
Q9GQ00	—	0.985	Q9GQ00 →
GLRA2	Glycine receptor subunit alpha-2	0.984	landscape →
Q61603	—	0.984	Q61603 →
GABRP	Gamma-aminobutyric acid receptor subunit pi (	0.984	landscape →
Q5EA06	—	0.984	Q5EA06 →
Q17328	—	0.984	Q17328 →
P57695	—	0.983	P57695 →
F1R8P4	—	0.983	F1R8P4 →
P23414	—	0.982	P23414 →
P24524	—	0.982	P24524 →
P09484	—	0.982	P09484 →
P48168	—	0.982	P48168 →
P12392	—	0.982	P12392 →
P22771	—	0.982	P22771 →
P07727	—	0.982	P07727 →
Q9ERK7	—	0.982	Q9ERK7 →
P02712	—	0.981	P02712 →
O93430	—	0.981	O93430 →
GLRB	Glycine receptor subunit beta (Glycine recept	0.981	landscape →
O09028	—	0.981	O09028 →
P20781	—	0.981	P20781 →