SCHEMBL2850867

SCHEMBL2850867

CCC1=Cc2c(cccc2-c2ccccc2)[CH]1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDCD1 Q15116 1/20 0.36
CD274 Q9NZQ7 1/20 0.36
SETD7 Q8WTS6 2/20 0.34
DPP4 P27487 1/20 0.32
ALDH1A1 P00352 4/20 0.31
HSD17B10 Q99714 3/20 0.31
HPGD P15428 1/20 0.31
BCL2L1 Q07817 1/20 0.31
CYP2A6 P11509 1/20 0.31
MAPK1 P28482 1/20 0.31
ADRB2 P07550 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
PLK4 O00444 1/20 0.31
MAPK9 P45984 1/20 0.31
LIMK1 P53667 1/20 0.31
CLK4 Q9HAZ1 1/20 0.31
AKT3 Q9Y243 1/20 0.31
METAP2 P50579 1/20 0.31
PPARG P37231 1/20 0.31
PPARA Q07869 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27504828 0.98 PDCD1 (0.35) PDCD1CD274SETD7DPP4ALDH1A1
SCHEMBL27510452 0.98 PDCD1 (0.35) PDCD1CD274SETD7DPP4ALDH1A1
SCHEMBL27463817 0.95 PDCD1 (0.33) PDCD1CD274SETD7DPP4CYP2A6
SCHEMBL27464626 0.95 PDCD1 (0.33) PDCD1CD274SETD7DPP4CYP2A6
SCHEMBL27464202 0.94 PDCD1 (0.33) PDCD1CD274SETD7
SCHEMBL27464629 0.94 PDCD1 (0.33) PDCD1CD274SETD7ALDH1A1MAPK1
SCHEMBL27477687 0.94 PDCD1 (0.33) PDCD1CD274SETD7CYP2A6
SCHEMBL27428051 0.94 PDCD1 (0.33) PDCD1CD274SETD7CYP2A6
SCHEMBL27547873 0.88 ADORA3 (0.35) SETD7PTAFRHTR7ADORA3
SCHEMBL27687608 0.87 ADORA3 (0.34) PTAFRADORA3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 176 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0779295-B1 Metallocenes BASELL POLYOLEFINE GMBH (DE) 2004-10-20 EP claimed
EP-0779306-B1 Process for preparation of cycloolefin copolymers TICONA GMBH (DE) 2003-12-03 EP claimed
EP-1134227-A2 Methylene-bridged biscyclopentadienyl compounds Basell Polyolefine GmbH (DE) 2001-09-19 EP claimed
WO-2001053356-A1 CATALYST SYSTEM WITH A SELECTED TRANSITION METAL: COCATALYST RATIO BASELL POLYOLEFINE GMBH (DE) 2001-07-26 WO claimed
US-6255508-B1 COORDINATION CATALYST; ALPHA-OLEFIN POLYMERIZATION CATALYST TARGOR GMBH (DE) 2001-07-03 US claimed
US-5945553-A Process for preparing a methylene-bridged biscyclopentadienyl compound TARGOR GMBH (DE) 1999-08-31 US claimed
US-5808122-A Organometallic compound HOECHST AKTIENGESELLSCHAFT (DE) 1998-09-15 US claimed
US-5733990-A Catalyst for producing polyolefin and process for producing polyolefin DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1998-03-31 US claimed
US-5726333-A POLYMERIZATION CATALYSTS HOECHST AG (DE) 1998-03-10 US claimed
US-5677255-A COMPLEX OF GROUP 4A METAL ON ORGANOSILICON POLYMER DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1997-10-14 US claimed
WO-2022059765-A1 METHOD FOR PRODUCING ION-EXCHANGEABLE LAYERED SILICATE SALT PARTICLES, METHOD FOR PRODUCING OLEFIN POLYMERIZATION CATALYST COMPONENT, METHOD FOR PRODUCING OLEFIN POLYMERIZATION CATALYST, AND METHOD FOR PRODUCING OLEFIN POLYMER USING SAME 日本ポリプロ株式会社 2022-03-24 WO disclosed
WO-2020203274-A1 PRODUCTION METHOD FOR CATALYST COMPONENT FOR OLEFIN POLYMERIZATION, PRODUCTION METHOD FOR CATALYST FOR OLEFIN POLYMERIZATION, AND PRODUCTION METHOD FOR OLEFIN POLYMER 日本ポリプロ株式会社 2020-10-08 WO disclosed
CN-104136525-B Propylene-ethylene copolymers resin combination with and formed body, film and sheet material JAPAN POLYPROPYLENE CORP. (JP) 2016-05-25 CN disclosed
CN-104136525-A Propylene-ethylene copolymer resin composition, and molded product, film and sheet thereof JAPAN POLYPROPYLENE CORP 2014-11-05 CN disclosed
CN-1946748-B Metallocene ligands, metallocene compounds and metallocene catalysts, their synthesis and their use for the polymerization of olefins NOVOLEN TECH HOLDINGS CV 2011-04-06 CN disclosed
EP-0694557-A2 Organo metallic compounds HOECHST AKTIENGESELLSCHAFT (DE) 1996-01-31 EP disclosed
CN-1109061-A Metallocenic compound HOECHST AG (DE) 1995-09-27 CN disclosed
CN-1107854-A Metalocenes compound HOECHST AG (DE) 1995-09-06 CN disclosed
CN-1107162-A Metallocen method for preparation of same and application of same as catalyst HOECHST AG (DE) 1995-08-23 CN disclosed
EP-0654476-A1 Metallocenes, their preparation and use as catalysts HOECHST AKTIENGESELLSCHAFT (DE) 1995-05-24 EP disclosed