Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | INSR | P06213 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | CHUK | O15111 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.43 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.42 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28506118 | 0.82 | DYRK1A (0.51) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL21590277 | 0.81 | MAP4K1 (0.46) | DYRK1APOLBSMN1; SMN2LMNAPKM | |
| SCHEMBL21590316 | 0.81 | DYRK1A (0.49) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL28502220 | 0.80 | DYRK1A (0.54) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL28502428 | 0.80 | RIPK1 (0.54) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL28504554 | 0.80 | BRD4 (0.58) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL28905250 | 0.79 | DYRK1A (0.48) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL858396 | 0.79 | RIPK1 (0.51) | DYRK1AINSRCDK2ABL1FLT3 | |
| SCHEMBL28499630 | 0.77 | FLT3 (0.56) | DYRK1AINSRCDK2IKBKBCHUK | |
| SCHEMBL21590171 | 0.76 | RIPK1 (0.50) | DYRK1AINSRCDK2IKBKBCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |