Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.48 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | CLK2 | P49760 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.48 |
| ▸ | PLK4 | O00444 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | PRKCG | P05129 | 1/20 | 0.48 |
| ▸ | INSR | P06213 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.48 |
| ▸ | FES | P07332 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4828101 | 0.87 | AURKA (0.54) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL28046056 | 0.87 | BRAF (0.53) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL9887961 | 0.84 | AURKA (0.46) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL7520159 | 0.84 | AURKA (0.46) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL15882691 | 0.84 | DYRK1A (0.48) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL4831062 | 0.84 | DYRK1A (0.48) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL1516568 | 0.84 | DYRK1A (0.48) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL9281242 | 0.83 | AURKA (0.44) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL8167329 | 0.83 | AURKA (0.50) | DYRK1AAURKAJAK2PRKD3MAP4K4 | |
| SCHEMBL1516742 | 0.81 | CDK2 (0.46) | DYRK1AAURKAJAK2PRKD3MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |