Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 11/20 | 1.00 |
| ▸ | KIT | P10721 | 10/20 | 1.00 |
| ▸ | AURKA | O14965 | 1/20 | 0.78 |
| ▸ | EGFR | P00533 | 1/20 | 0.78 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.78 |
| ▸ | IGF1R | P08069 | 1/20 | 0.78 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.78 |
| ▸ | CDK2 | P24941 | 1/20 | 0.78 |
| ▸ | BMX | P51813 | 1/20 | 0.78 |
| ▸ | JAK3 | P52333 | 1/20 | 0.78 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.78 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.78 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.78 |
| ▸ | PTK2 | Q05397 | 5/20 | 0.68 |
| ▸ | SYK | P43405 | 1/20 | 0.66 |
| ▸ | ULK1 | O75385 | 2/20 | 0.64 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.64 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28519550 | 0.89 | FLT3 (1.00) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL1916487 | 0.89 | FLT3 (0.85) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL28522032 | 0.89 | FLT3 (1.00) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL28507163 | 0.86 | FLT3 (1.00) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL28512968 | 0.83 | FLT3 (1.00) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL28517796 | 0.83 | FLT3 (1.00) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL28512856 | 0.82 | FLT3 (0.72) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL28514104 | 0.82 | FLT3 (1.00) | FLT3KITAURKAEGFRNTRK1 | |
| SCHEMBL17545176 | 0.82 | ULK1 (0.88) | FLT3KITULK1ULK2 | |
| SCHEMBL28519559 | 0.82 | FLT3 (0.82) | FLT3KITAURKAEGFRNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111732548-A | N2-carbamyl aromatic ring-2-aminopyrimidine derivatives and medical application thereof | UNIV ZHEJIANG | 2020-10-02 | — | — | CN | claimed |
| CN-111732548-B | N2-carbamyl aromatic ring-2-aminopyrimidine derivatives and medical application thereof | 浙江大学 | 2022-06-17 | — | — | CN | disclosed |
| CN-111732548-A | N2-carbamyl aromatic ring-2-aminopyrimidine derivatives and medical application thereof | UNIV ZHEJIANG | 2020-10-02 | — | — | CN | disclosed |