Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 15/20 | 0.54 |
| ▸ | PDPK1 | O15530 | 4/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL720228 | 0.83 | ALK (0.57) | ALKPDPK1TNIK | |
| SCHEMBL16344211 | 0.83 | PDPK1 (0.58) | ALKPDPK1 | |
| SCHEMBL28506207 | 0.82 | ALK (0.48) | ALKPDPK1 | |
| SCHEMBL28503574 | 0.81 | PAK1 (0.56) | PDPK1TNIK | |
| SCHEMBL9888143 | 0.80 | ALK (0.51) | ALKPDPK1TNIK | |
| SCHEMBL9284633 | 0.80 | ALK (0.56) | ALKPDPK1 | |
| SCHEMBL9278508 | 0.80 | ALK (0.54) | ALKPDPK1TNIK | |
| SCHEMBL15253627 | 0.79 | ALK (0.48) | ALKPDPK1 | |
| SCHEMBL28481416 | 0.78 | PDPK1 (0.51) | ALKPDPK1 | |
| SCHEMBL9887923 | 0.77 | ALK (0.48) | ALKPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |