Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 12/20 | 0.56 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.53 |
| ▸ | MET | P08581 | 4/20 | 0.50 |
| ▸ | PAK4 | O96013 | 3/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.48 |
| ▸ | SIK1 | P57059 | 1/20 | 0.48 |
| ▸ | SIK3 | Q9Y2K2 | 1/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28512236 | 0.81 | ALK (0.54) | TNIKPDPK1 | |
| SCHEMBL21592674 | 0.80 | MAP3K11 (0.61) | PAK1TNIKPAK4SIK1SIK3 | |
| SCHEMBL31435909 | 0.79 | TNIK (0.55) | PAK1TNIKPAK4SIK1SIK3 | |
| SCHEMBL19860027 | 0.78 | SIK1 (0.65) | PAK1TNIKMETPAK4SIK1 | |
| SCHEMBL21776509 | 0.78 | MET (0.55) | METIKBKETBK1 | |
| SCHEMBL30388408 | 0.78 | MET (0.55) | METIKBKETBK1 | |
| SCHEMBL28502521 | 0.77 | DYRK1A (0.64) | PAK1TNIKMETIKBKETBK1 | |
| SCHEMBL15799467 | 0.76 | SIK1 (0.82) | PAK1TNIKMETPAK4SIK1 | |
| SCHEMBL15799697 | 0.76 | TNIK (0.52) | PAK1TNIKMETPAK4SIK1 | |
| SCHEMBL21626734 | 0.76 | MET (0.56) | PAK1TNIKMETPAK4SIK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |