Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 20/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20350477 | 0.87 | PTPN11 (0.53) | PTPN11KCNH2 | |
| SCHEMBL23024432 | 0.85 | PTPN11 (0.59) | PTPN11KCNH2MAPK3MAPK1 | |
| Hydrochloric Acid SCHEMBL21383923 | 0.84 | PTPN11 (0.58) | PTPN11KCNH2MAPK3MAPK1 | |
| Hydrochloric Acid SCHEMBL23024532 | 0.84 | PTPN11 (0.58) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL31657077 | 0.84 | PTPN11 (0.52) | PTPN11KCNH2 | |
| SCHEMBL31657083 | 0.83 | PTPN11 (0.72) | PTPN11KCNH2 | |
| SCHEMBL20350465 | 0.82 | PTPN11 (0.51) | PTPN11KCNH2 | |
| SCHEMBL28506515 | 0.82 | PTPN11 (0.65) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL20350461 | 0.81 | PTPN11 (0.54) | PTPN11KCNH2MAPK3MAPK1 | |
| SCHEMBL20350644 | 0.81 | PTPN11 (0.50) | PTPN11KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112166110-B | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2023-08-11 | — | — | CN | disclosed |
| CN-112166110-A | SHP2 phosphatase inhibitors and methods of use thereof | 传达治疗有限公司 | 2021-01-01 | — | — | CN | disclosed |