Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 2/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2862242 | 0.86 | BRAF (0.47) | BRAFDYRK1APDPK1FSCN1KDR | |
| SCHEMBL2858259 | 0.85 | CLK1 (0.51) | BRAFDYRK1APDPK1FSCN1RAB9A | |
| SCHEMBL2853481 | 0.84 | EPHX2 (0.41) | BRAFABL1BCRRAB9ASMN1; SMN2 | |
| SCHEMBL3512217 | 0.82 | BRAF (0.46) | BRAFDYRK1APDPK1FSCN1KDR | |
| SCHEMBL2851409 | 0.82 | BRAF (0.62) | BRAFDYRK1APDPK1FSCN1PDGFRB | |
| SCHEMBL2856446 | 0.81 | DYRK1A (0.46) | BRAFDYRK1APDPK1FSCN1RAB9A | |
| SCHEMBL2856064 | 0.80 | BRAF (0.44) | BRAFDYRK1APDPK1FSCN1RAB9A | |
| SCHEMBL14949669 | 0.79 | BRAF (0.55) | BRAFABL1BCRPDGFRBKIT | |
| SCHEMBL2860133 | 0.78 | KDR (0.55) | BRAFDYRK1AABL1PDGFRBKIT | |
| SCHEMBL2849273 | 0.77 | KDR (0.53) | BRAFPDGFRBKITFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2247620-A1 | ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE | Genentech, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |
| EP-2176296-A1 | ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE | Genetech, Inc. (US) | 2010-04-21 | — | — | EP | disclosed |
| WO-2009099728-A1 | ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009012268-A1 | ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE | GENENTECH, INC. (US) | 2009-01-22 | — | — | WO | disclosed |