Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.55 |
| ▸ | KDR | P35968 | 14/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 4/20 | 0.45 |
| ▸ | BCR | P11274 | 1/20 | 0.45 |
| ▸ | MET | P08581 | 4/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2859325 | 0.88 | KDR (0.53) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL12892687 | 0.87 | BRAF (0.71) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2860133 | 0.87 | KDR (0.55) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL1259251 | 0.87 | MET (0.55) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL1258338 | 0.86 | BRAF (0.56) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2859622 | 0.82 | KDR (0.72) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2855459 | 0.82 | BRAF (0.57) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL1258993 | 0.82 | BRAF (0.57) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL14949680 | 0.82 | MET (0.44) | KDRABL1BCRMET | |
| SCHEMBL1259902 | 0.81 | MET (0.62) | KDRPDGFRBKITFLT1MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445509-B2 | Fused heterocyclic derivatives and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2013-05-21 | — | — | US | disclosed |