Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 2/20 | 0.77 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | RIPK3 | Q9Y572 | 16/20 | 0.56 |
| ▸ | RIPK1 | Q13546 | 12/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2851409 | 0.87 | BRAF (0.62) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2452675 | 0.86 | BRAF (0.67) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2453008 | 0.86 | BRAF (0.69) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2454632 | 0.85 | BRAF (0.70) | BRAFKDRRIPK3RIPK1 | |
| SCHEMBL15946928 | 0.85 | BRAF (0.67) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2454025 | 0.84 | KDR (0.70) | BRAFKDRRIPK3RIPK1 | |
| SCHEMBL2452470 | 0.84 | BRAF (0.69) | BRAFKDRRIPK3RIPK1 | |
| SCHEMBL2455839 | 0.84 | BRAF (0.64) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2855459 | 0.84 | BRAF (0.57) | BRAFKDRRIPK3RIPK1PDGFRB | |
| SCHEMBL2453162 | 0.84 | BRAF (0.66) | BRAFKDRRIPK3RIPK1PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2399921-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-08-12 | — | — | EP | disclosed |
| US-8697874-B2 | Heterocyclic compound and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2014-04-15 | — | — | US | disclosed |
| EP-2399921-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2011-12-28 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |