Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.44 |
| ▸ | RIPK3 | Q9Y572 | 7/20 | 0.42 |
| ▸ | RIPK1 | Q13546 | 5/20 | 0.42 |
| ▸ | IKBKB | O14920 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2857442 | 0.87 | BRAF (0.45) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2851233 | 0.87 | BRAF (0.54) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2854029 | 0.85 | KDR (0.56) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2851381 | 0.84 | BRAF (0.77) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2864471 | 0.83 | BRAF (0.37) | BRAFKDRABL1LCKNPC1 | |
| SCHEMBL13185064 | 0.83 | BRAF (0.53) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2856273 | 0.83 | BRAF (0.54) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL14949669 | 0.82 | BRAF (0.55) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL3510114 | 0.82 | BRAF (0.54) | BRAFKDRPDGFRBKITFLT1 | |
| SCHEMBL2853332 | 0.81 | BRAF (0.55) | BRAFKDRPDGFRBKITFLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2184285-B1 | HETEROCYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL (JP) | 2015-11-04 | — | — | EP | disclosed |
| EP-2184285-A1 | HETEROCYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2010-05-12 | — | — | EP | disclosed |