Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.76 |
| ▸ | RET | P07949 | 3/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | PRKCA | P17252 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30167109 | 0.90 | EGFR (0.64) | EGFRRETERBB2AURKBCLK4 | |
| SCHEMBL21331884 | 0.90 | EGFR (0.64) | EGFRRETERBB2AURKBCLK4 | |
| SCHEMBL21331750 | 0.88 | EGFR (0.74) | EGFRRETDYRK1ACLK4DYRK1B | |
| SCHEMBL30167186 | 0.88 | EGFR (0.61) | EGFRERBB2AURKBCLK4MAPT | |
| SCHEMBL21331758 | 0.87 | EGFR (1.00) | EGFR | |
| SCHEMBL30167153 | 0.86 | EGFR (0.59) | EGFRRETERBB2DYRK1AAURKB | |
| SCHEMBL30167177 | 0.85 | EGFR (0.61) | EGFRRETERBB2DYRK1ADYRK1B | |
| SCHEMBL21345572 | 0.85 | EGFR (0.64) | EGFRRETDYRK1ADYRK1BMAPT | |
| SCHEMBL21333844 | 0.84 | EGFR (1.00) | EGFRRETABCG2TSHRHTT | |
| SCHEMBL28907418 | 0.84 | EGFR (0.73) | EGFRERBB2DYRK1ADYRK1BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110229172-B | Acyl-substituted oxazine quinazoline compound, preparation method and application thereof | 北京赛特明强医药科技有限公司 | 2020-12-25 | — | — | CN | disclosed |