Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 2/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.42 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.40 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29198633 | 0.90 | MRGPRX4 (0.44) | MRGPRX4CYP19A1MAPTMAPK1TDP1 | |
| SCHEMBL21647406 | 0.89 | KDM4E (0.40) | MRGPRX4CYP19A1MAPTMAPK1TDP1 | |
| SCHEMBL21647514 | 0.88 | KDM4E (0.41) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL21647535 | 0.88 | KDM4E (0.41) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL25360195 | 0.88 | KDM4E (0.41) | MRGPRX4MAPTMAPK1TDP1L3MBTL1 | |
| SCHEMBL28541204 | 0.87 | MRGPRX4 (0.45) | MRGPRX4MAOB | |
| SCHEMBL29285393 | 0.86 | KEAP1 (0.43) | CYP19A1MAPTTDP1L3MBTL1MAOB | |
| SCHEMBL10511076 | 0.85 | MRGPRX4 (0.46) | MRGPRX4CYP19A1MAPTMAPK1TDP1 | |
| SCHEMBL8369436 | 0.84 | MAPT (0.49) | MRGPRX4CYP19A1MAPTMAPK1TDP1 | |
| SCHEMBL21815478 | 0.84 | MEN1 (0.47) | MAPTMAPK1L3MBTL1LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115038704-A | Nitrogen oxide donating PDE-5 and/or PDE-6 inhibitor compounds | 日东制药股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-112261970-A | 3- (5-hydroxy-1-oxoisoindolin-2-yl) piperidine-2, 6-dione derivatives and their use in the treatment of IKAROS family Zinc finger 2(IKZF2) dependent diseases | 诺华股份有限公司 | 2021-01-22 | — | — | CN | disclosed |
| CN-112218859-A | Modulators of proteolysis and related methods of use | 阿尔维纳斯运营股份有限公司 | 2021-01-12 | — | — | CN | disclosed |