Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 7/20 | 0.42 |
| ▸ | HTR2B | P41595 | 6/20 | 0.42 |
| ▸ | HTR2A | P28223 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene Glycol SCHEMBL6449088 | 0.90 | TSHR (0.77) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| Hydrogen Peroxide SCHEMBL28927927 | 0.85 | TSHR (0.94) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| Alcohol SCHEMBL8767673 | 0.83 | TSHR (0.74) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL28467238 | 0.82 | TSHR (1.00) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL1943997 | 0.82 | — | — | |
| SCHEMBL21026 | 0.82 | — | — | |
| SCHEMBL987488 | 0.82 | — | — | |
| Methyl Alcohol SCHEMBL8766879 | 0.81 | TSHR (0.85) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4282078 | 0.80 | TSHR (0.94) | TSHRCHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL20981569 | 0.80 | TSHR (0.94) | TSHRCHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117447420-A | Method for synthesizing tetramidazole hydrochloride intermediate hydroxy salt by utilizing micro-channel technology | 苏州华道生物药业股份有限公司 | 2024-01-26 | — | — | CN | disclosed |
| CN-112194639-A | Preparation method of tetramisole intermediate hydroxyl salt | 江苏天和制药有限公司 | 2021-01-08 | — | — | CN | disclosed |