Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.64 |
| ▸ | HTT | P42858 | 2/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20423694 | 0.88 | KMT2A (0.68) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL2388387 | 0.85 | MAPT (0.62) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL5573222 | 0.85 | MAPT (0.76) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL29803251 | 0.85 | MAPT (0.69) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL12720262 | 0.85 | KMT2A (0.64) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL30182423 | 0.85 | MAPT (0.69) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL13218466 | 0.84 | GPR119 (0.79) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL1481563 | 0.82 | GPR119 (0.78) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL63633 | 0.82 | MAPT (0.65) | SMN1; SMN2MAPTLMNAKMT2AMEN1 | |
| SCHEMBL24891935 | 0.82 | MAPT (0.62) | SMN1; SMN2MAPTLMNAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110305062-B | Substituted isoquinolone compound and synthesis method and application thereof | 广州医科大学 | 2021-01-05 | — | — | CN | disclosed |