Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.47 |
| ▸ | TSHR | P16473 | 5/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.47 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.47 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.47 |
| ▸ | GABRR1 | P24046 | 4/20 | 0.40 |
| ▸ | GABRR2 | P28476 | 3/20 | 0.40 |
| ▸ | BLM | P54132 | 3/20 | 0.40 |
| ▸ | GABRR3 | A8MPY1 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | APEX1 | P27695 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | KDM5C | P41229 | 2/20 | 0.39 |
| ▸ | PHF8 | Q9UPP1 | 2/20 | 0.39 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyric Acid SCHEMBL29173646 | 0.86 | FFAR3 (0.56) | TSHREGLN1TP53EGLN3TDP1 | |
| SCHEMBL34552 | 0.86 | — | — | |
| Fumaric Acid SCHEMBL4337405 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL4304790 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53EGLN3 | |
| Fumaric Acid SCHEMBL4042292 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4400079 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53ALKBH5 | |
| SCHEMBL1164653 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53EGLN3 | |
| Fumaric Acid SCHEMBL2390060 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4337403 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4042291 | 0.86 | TSHR (0.64) | LMNATSHREGLN1TP53ALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443134-A | Conjugates of cell binding molecules and camptothecin analogs | 杭州多禧生物科技有限公司 | 2022-12-06 | — | — | CN | disclosed |
| CN-113195487-A | 2, 3-diaminosuccinyl conjugate linkers | 杭州多禧生物科技有限公司 | 2021-07-30 | — | — | CN | disclosed |
| CN-112272669-A | Cross-linked pyrrolobenzodiazepine dimer (PBD) derivatives and conjugates thereof | 杭州多禧生物科技有限公司 | 2021-01-26 | — | — | CN | disclosed |