Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.64 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.64 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.64 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.47 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | GABRR1 | P24046 | 3/20 | 0.43 |
| ▸ | GABRR2 | P28476 | 2/20 | 0.43 |
| ▸ | BLM | P54132 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL4042291 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL27498394 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4337405 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4042292 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL2390060 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL725507 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL4400079 | 1.00 | TSHR (0.64) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Fumaric Acid SCHEMBL10458273 | 0.97 | TSHR (0.60) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL29222106 | 0.97 | TSHR (0.60) | TSHRLMNAEGLN1TP53ALKBH5 | |
| Maleic Acid SCHEMBL27558801 | 0.94 | TSHR (0.56) | TSHRLMNAEGLN1TP53ALKBH5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2117607-A1 | IMAGING AGENTS AND METHODS OF USE THEREOF | HUNTINGTON MEDICAL RESEARCH INSTITUTES (US) | 2009-11-18 | — | — | EP | disclosed |
| WO-2008086534-A1 | IMAGING AGENTS AND METHODS OF USE THEREOF | HUNTINGTON MEDICAL RESEARCH INSTITUTES (US) | 2008-07-17 | — | — | WO | disclosed |