Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 17/20 | 1.00 |
| ▸ | EED | O75530 | 2/20 | 0.62 |
| ▸ | SUZ12 | Q15022 | 2/20 | 0.62 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.62 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.62 |
| ▸ | EZH1 | Q92800 | 6/20 | 0.60 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28521908 | 0.93 | EZH2 (0.87) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL19503400 | 0.88 | EZH2 (0.80) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL19503402 | 0.88 | EZH2 (0.78) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL30022137 | 0.87 | EZH2 (0.77) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL28520970 | 0.87 | EZH2 (0.77) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL30021515 | 0.82 | EZH2 (0.69) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL15390253 | 0.81 | EZH2 (0.72) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL21917061 | 0.81 | EZH2 (0.67) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL16115555 | 0.80 | EZH2 (0.67) | EZH2EEDSUZ12RBBP4AEBP2 | |
| Acrylamide SCHEMBL28524020 | 0.79 | EZH2 (0.66) | EZH2EEDSUZ12EZH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341390-B | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-112341390-A | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2021-02-09 | — | — | CN | disclosed |