Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 18/20 | 0.87 |
| ▸ | EED | O75530 | 8/20 | 0.72 |
| ▸ | SUZ12 | Q15022 | 8/20 | 0.72 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.72 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.72 |
| ▸ | EZH1 | Q92800 | 4/20 | 0.59 |
| ▸ | RBBP7 | Q16576 | 2/20 | 0.59 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.59 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19503400 | 0.95 | EZH2 (0.80) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL28516505 | 0.93 | EZH2 (1.00) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL19503402 | 0.89 | EZH2 (0.78) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL15393260 | 0.83 | EZH2 (1.00) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL30021515 | 0.82 | EZH2 (0.69) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL21917048 | 0.82 | EZH2 (0.66) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL24227159 | 0.81 | EZH2 (0.62) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL21917060 | 0.81 | EZH2 (0.66) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL17734365 | 0.80 | EZH2 (0.63) | EZH2EEDSUZ12RBBP4AEBP2 | |
| SCHEMBL28520970 | 0.80 | EZH2 (0.77) | EZH2EEDSUZ12RBBP4AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112341390-B | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2022-08-23 | — | — | CN | disclosed |
| CN-112341390-A | Compound for preparing targeted histone methyltransferase EZH2 covalent inhibitor and preparation method and application thereof | 四川大学 | 2021-02-09 | — | — | CN | disclosed |