Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 8/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567873 | 1.00 | GAA (0.49) | GAASYKAURKBINCENPMEN1 | |
| SCHEMBL25213409 | 0.80 | SYK (0.46) | GAASYKAURKBINCENPMEN1 | |
| SCHEMBL2760112 | 0.80 | SYK (0.59) | GAASYKAURKBINCENPMEN1 | |
| SCHEMBL25213830 | 0.78 | SYK (0.46) | GAASYKAURKBINCENPMEN1 | |
| SCHEMBL19089278 | 0.77 | SYK (0.67) | GAASYKAURKBINCENPEGFR | |
| SCHEMBL31530287 | 0.77 | GAA (0.57) | GAASYKTP53SMN1; SMN2EGFR | |
| SCHEMBL22874612 | 0.76 | SYK (0.53) | SYKAURKBINCENPKMT2AEGFR | |
| SCHEMBL4174306 | 0.76 | ALDH1A1 (0.47) | GAASMN1; SMN2MAPK1TDP1L3MBTL1 | |
| SCHEMBL13940197 | 0.75 | ENPP1 (0.47) | MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15075236 | 0.74 | SYK (0.69) | SYKAURKBINCENPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112279838-B | Preparation method of pyrroltinib | 苏州富士莱医药股份有限公司 | 2021-07-13 | — | — | CN | claimed |
| CN-112279838-A | Preparation method of pyrroltinib | 苏州富士莱医药股份有限公司 | 2021-01-29 | — | — | CN | claimed |
| CN-112279838-B | Preparation method of pyrroltinib | 苏州富士莱医药股份有限公司 | 2021-07-13 | — | — | CN | disclosed |
| CN-112279838-A | Preparation method of pyrroltinib | 苏州富士莱医药股份有限公司 | 2021-01-29 | — | — | CN | disclosed |