Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.38 |
| ▸ | GSK3B | P49841 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MELK | Q14680 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28517264 | 1.00 | HRH3 (0.38) | HRH3GSK3BMAPK1MAPTCCNE1 | |
| SCHEMBL21590149 | 0.79 | HRH3 (0.51) | HRH3GSK3BMAPK1MAPTCCNE1 | |
| SCHEMBL21590190 | 0.79 | HRH3 (0.51) | HRH3GSK3BMAPK1MAPTCCNE1 | |
| SCHEMBL21590260 | 0.79 | HRH3 (0.51) | HRH3GSK3BMAPK1MAPTCCNE1 | |
| SCHEMBL28499871 | 0.78 | MELK (0.49) | MAPTKDM4EMELKHRH4PDE3B | |
| SCHEMBL28510928 | 0.77 | MAPK1 (0.39) | HRH3GSK3BMAPK1CCNE1CDK2 | |
| SCHEMBL28510930 | 0.77 | MAPK1 (0.39) | HRH3GSK3BMAPK1CCNE1CDK2 | |
| SCHEMBL19003699 | 0.71 | SMN1; SMN2 (0.47) | HRH3GSK3BMAPK1MAPTLMNA | |
| SCHEMBL2610122 | 0.71 | SMN1; SMN2 (0.47) | HRH3GSK3BMAPK1MAPTLMNA | |
| SCHEMBL27372185 | 0.71 | SMN1; SMN2 (0.47) | HRH3GSK3BMAPK1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112243439-A | Pyrrolo [2,3-B ] pyridines or pyrrolo [2,3-B ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2021-01-19 | — | — | CN | disclosed |