Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.61 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.61 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.61 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.61 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | NR3C1 | P04150 | 4/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2854123 | 0.90 | TRPC1 (0.63) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2856215 | 0.90 | MAPT (0.66) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2855555 | 0.89 | TRPC1 (0.61) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2849153 | 0.83 | MAPT (0.56) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2850770 | 0.83 | TRPC1 (0.53) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL8140350 | 0.82 | MAPT (0.71) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2854006 | 0.80 | NPC1 (0.54) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2852124 | 0.79 | TRPC1 (0.51) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL2853811 | 0.79 | SMN1; SMN2 (0.60) | MAPTTRPC1TRPC3STIM1ORAI1 | |
| SCHEMBL21929518 | 0.77 | NPC1 (0.55) | MAPTTRPC1TRPC3STIM1ORAI1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |