Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.55 |
| ▸ | AXL | P30530 | 1/20 | 0.55 |
| ▸ | MALT1 | Q9UDY8 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TRPC1 | P48995 | 1/20 | 0.48 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.48 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.48 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.48 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | FLT1 | P17948 | 2/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2855512 | 0.85 | MALT1 (0.55) | MAPTMETAXLMALT1KDM4E | |
| SCHEMBL2852073 | 0.83 | MAPT (0.71) | MAPTMETAXLKDM4EALDH1A1 | |
| SCHEMBL2855275 | 0.83 | MAPT (0.45) | MAPTMETAXLKDM4ENPC1 | |
| SCHEMBL2856272 | 0.81 | MALT1 (0.53) | METAXLMALT1KDM4EALDH1A1 | |
| SCHEMBL2856196 | 0.80 | MAPT (0.70) | MAPTKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL2850397 | 0.78 | MALT1 (0.57) | MAPTMETAXLMALT1KDM4E | |
| SCHEMBL2850244 | 0.78 | MALT1 (0.51) | MAPTMETAXLMALT1KDM4E | |
| SCHEMBL2858127 | 0.78 | ALDH1A1 (0.74) | MAPTMETAXLKDM4EALDH1A1 | |
| SCHEMBL21929518 | 0.76 | NPC1 (0.55) | MAPTMETAXLKDM4EALDH1A1 | |
| SCHEMBL2855560 | 0.76 | ALDH1A1 (0.49) | MAPTMETAXLKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | claimed |
| EP-1451160-B1 | PYRAZOLE-AMIDES FOR USE IN THE TREATMENT OF PAIN | ICAGEN INC (US) | 2010-01-13 | — | — | EP | disclosed |