Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL21591807 | 0.78 | TSHR (0.37) | — | |
| SCHEMBL29463955 | 0.77 | — | — | |
| SCHEMBL6113101 | 0.75 | ELANE (0.42) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| SCHEMBL9326229 | 0.73 | ELANE (0.41) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| SCHEMBL28653916 | 0.71 | ELANE (0.39) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| SCHEMBL29121 | 0.71 | DGAT1 (0.46) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| SCHEMBL8503697 | 0.70 | ELANE (0.38) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| SCHEMBL6308085 | 0.70 | ELANE (0.38) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| SCHEMBL11877904 | 0.69 | ELANE (0.36) | ELANEDGAT1HDAC1HDAC2HDAC6 | |
| Fluoride SCHEMBL2692246 | 0.68 | DGAT1 (0.43) | ELANEDGAT1HDAC1HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077994-B1 | IMIDAZOLIDINE DERIVATIVES, THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | SANOFI AVENTIS DEUTSCHLAND (DE) | 2010-01-20 | — | — | EP | disclosed |
| EP-0918059-B1 | Substituted imidazoline derivatives, their preparation, their use, and pharmaceutical compositions containing them | AVENTIS PHARMA GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| EP-1077994-A1 | IMIDAZOLIDINE DERIVATIVES, THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | Aventis Pharma Deutschland GmbH (DE) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999060015-A1 | IMIDAZOLIDINE DERIVATIVES, THE PRODUCTION THEREOF, THEIR USE AND PHARMACEUTICAL PREPARATIONS CONTAINING THE SAME | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 1999-11-25 | — | — | WO | disclosed |
| EP-0918059-A1 | Substituted imidazoline derivatives, their preparation, their use, and pharmaceutical compositions containing them | Hoechst Marion Roussel Deutschland GmbH (DE) | 1999-05-26 | — | — | EP | disclosed |