Thiophene

Thiophene

SCHEMBL28522796

CC(C)(C)c1ccc2ocnc2c1.c1ccsc1

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DYRK1A Q13627 1/20 0.38
MEN1 O00255 1/20 0.37
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37
KMT2A Q03164 1/20 0.37
CTNNB1 P35222 4/20 0.37
WNT3A P56704 4/20 0.37
NPC1 O15118 2/20 0.37
RAB9A P51151 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
TRPM5 Q9NZQ8 1/20 0.35
TRPV1 Q8NER1 1/20 0.34
NAMPT P43490 1/20 0.33
CNR2 P34972 1/20 0.32
PON1 P27169 1/20 0.32
GFER P55789 1/20 0.31
KCNH2 Q12809 1/20 0.31
SCN10A Q9Y5Y9 1/20 0.31
F2RL3 Q96RI0 3/20 0.31
ESR1 P03372 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2079591 0.89 DYRK1A (0.45) DYRK1AMEN1ALDH1A1GAAKMT2A
SCHEMBL29384003 0.89 DYRK1A (0.45) DYRK1AMEN1ALDH1A1GAAKMT2A
SCHEMBL18589868 0.76 DYRK1A (0.55) DYRK1AMEN1ALDH1A1GAAKMT2A
SCHEMBL18463899 0.76 DYRK1A (0.42) DYRK1AMEN1ALDH1A1GAAKMT2A
SCHEMBL2614339 0.75 DYRK1A (0.45) DYRK1AMEN1ALDH1A1GAAKMT2A
Thiophene SCHEMBL27996130 0.75 LMNA (0.32)
Benzo[D]Oxazole SCHEMBL2311728 0.73 NPC1 (0.37) DYRK1AMEN1ALDH1A1GAAKMT2A
Benzo[D]Oxazole SCHEMBL3260103 0.73 NPC1 (0.37) DYRK1AMEN1ALDH1A1GAAKMT2A
SCHEMBL29770908 0.73 MEN1 (0.43) DYRK1AMEN1ALDH1A1GAAKMT2A
SCHEMBL21191750 0.73 MEN1 (0.43) DYRK1AMEN1ALDH1A1GAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112236308-A Polyolefin compositions providing improved laser marking contrast 北欧化工公司 2021-01-15 CN claimed
CN-112236308-A Polyolefin compositions providing improved laser marking contrast 北欧化工公司 2021-01-15 CN disclosed