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SCHEMBL28522955

SCHEMBL28522955

CC(C)(C)OC(=O)N[C@H]1C[C@H](Oc2cnc(C(F)(F)F)nc2)C1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PIK3CD O00329 2/20 0.43
▸ BTK Q06187 1/20 0.39
▸ KMT2A Q03164 1/20 0.38
▸ L3MBTL1 Q9Y468 1/20 0.38
▸ EPHX2 P34913 2/20 0.38
▸ KDM1A O60341 2/20 0.37
▸ MAOB P27338 1/20 0.37
▸ CKS1B P61024 1/20 0.37
▸ SKP1 P63208 1/20 0.37
▸ SKP2 Q13309 1/20 0.37
▸ NFKB1 P19838 1/20 0.36
▸ NFKB2 Q00653 1/20 0.36
▸ RELA Q04206 1/20 0.36
▸ JAK1 P23458 3/20 0.36
▸ JAK2 O60674 1/20 0.36
▸ P2RX3 P56373 1/20 0.35
▸ P2RX2 Q9UBL9 1/20 0.35
▸ GAA P10253 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30152490 0.85 EPHX2 (0.44) PIK3CDKMT2AL3MBTL1EPHX2KDM1A
SCHEMBL23167949 0.85 EPHX2 (0.44) PIK3CDKMT2AL3MBTL1EPHX2KDM1A
SCHEMBL23167947 0.85 EPHX2 (0.44) PIK3CDKMT2AL3MBTL1EPHX2KDM1A
SCHEMBL24976933 0.85 EPHX2 (0.44) PIK3CDKMT2AL3MBTL1EPHX2KDM1A
SCHEMBL21503407 0.83 KMT2A (0.39) PIK3CDBTKKMT2AL3MBTL1EPHX2
SCHEMBL21491929 0.83 KMT2A (0.39) PIK3CDBTKKMT2AL3MBTL1EPHX2
SCHEMBL21492145 0.83 P2RX3 (0.38) EPHX2P2RX3P2RX2
SCHEMBL24975431 0.83 PIK3CD (0.44) PIK3CDBTKKMT2AL3MBTL1EPHX2
SCHEMBL29874666 0.82 EPHX2 (0.44) PIK3CDBTKKMT2AL3MBTL1EPHX2
SCHEMBL24921104 0.82 PIK3CD (0.45) PIK3CDBTKKMT2AL3MBTL1EPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12384790-B2 Pteridinone compounds and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2025-08-12 — — US disclosed
CN-112218865-B Pteridinone compounds and uses thereof 沃泰克斯药物股份有限公司 2024-03-12 — — CN disclosed
US-20230312587-A1 PTERIDINONE COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2023-10-05 — — US disclosed
US-11572364-B2 Pteridinone compounds and uses thereof VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-02-07 — — US disclosed
US-20220363685-A1 PTERIDINONE COMPOUNDS AND USES THEREOF VERTEX PHARMACEUTICALS INCORPORATED 2022-11-17 — — US disclosed
CN-112218865-A Pteridinone compounds and uses thereof 沃泰克斯药物股份有限公司 2021-01-12 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11572364-B2 Pteridinone compounds and uses thereof DPYD, PKD1, TYMP PIK3CD 1645/4885BTK 2261/4885KMT2A 909/4885
US-20220363685-A1 PTERIDINONE COMPOUNDS AND USES THEREOF DPYD, PKD1, TYMP PIK3CD 1645/4885BTK 2261/4885KMT2A 909/4885
US-20230312587-A1 PTERIDINONE COMPOUNDS AND USES THEREOF DPYD, PKD1, TYMP PIK3CD 1645/4885BTK 2261/4885KMT2A 909/4885
US-12384790-B2 Pteridinone compounds and uses thereof DPYD, PKD1, TYMP PIK3CD 1645/4885BTK 2261/4885KMT2A 909/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.