Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 3/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TAF1 | P21675 | 1/20 | 0.35 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12102100 | 0.81 | ADORA2A (0.46) | ADORA2AADORA1JAK2JAK1JAK3 | |
| SCHEMBL28510691 | 0.79 | KDM4E (0.51) | ADORA2AADORA1JAK2JAK1JAK3 | |
| SCHEMBL18321913 | 0.77 | ADORA2A (0.42) | ADORA2AADORA1JAK2JAK1JAK3 | |
| SCHEMBL28907542 | 0.73 | JAK3 (0.43) | ADORA2AADORA1JAK2JAK1JAK3 | |
| SCHEMBL29413023 | 0.72 | KAT2B (0.49) | BRD4TAF1BRPF1CREBBPCECR2 | |
| SCHEMBL28515190 | 0.72 | ADORA2B (0.40) | ADORA2AADORA1JAK2DYRK1ACYP1A2 | |
| SCHEMBL20894005 | 0.70 | JAK2 (0.43) | JAK2JAK1JAK3HRH4 | |
| SCHEMBL23505912 | 0.68 | PRKCI (0.43) | JAK2JAK1JAK3PRKCIAXL | |
| SCHEMBL30879806 | 0.68 | KDM4E (0.64) | RXFP1SMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL2611507 | 0.68 | KDM4E (0.64) | RXFP1SMN1; SMN2KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107722013-B | Deazapurine compounds, pharmaceutical compositions, preparation method and uses thereof | 中国科学院上海药物研究所 | 2021-01-12 | — | — | CN | disclosed |