Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 15/20 | 0.66 |
| ▸ | CDK4 | P11802 | 5/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.45 |
| ▸ | CCND1 | P24385 | 5/20 | 0.45 |
| ▸ | CDK2 | P24941 | 5/20 | 0.45 |
| ▸ | CCND3 | P30281 | 5/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 5/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.45 |
| ▸ | CDK9 | P50750 | 4/20 | 0.45 |
| ▸ | CDK7 | P50613 | 3/20 | 0.45 |
| ▸ | CCNH | P51946 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 3/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28521145 | 0.81 | DYRK2 (0.61) | DYRK2CDK6 | |
| SCHEMBL26447936 | 0.81 | DYRK2 (0.98) | DYRK2CDK4CCNA2CCND1CDK2 | |
| Hydrochloric Acid SCHEMBL30569704 | 0.80 | DYRK2 (1.00) | DYRK2CDK4CCNA2CCND1CDK2 | |
| Hydrochloric Acid SCHEMBL26679974 | 0.80 | DYRK2 (1.00) | DYRK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL30679279 | 0.79 | DYRK2 (1.00) | DYRK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL26447922 | 0.79 | DYRK2 (1.00) | DYRK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL26447925 | 0.79 | DYRK2 (0.98) | DYRK2CDK4CCNA2CCND1CDK2 | |
| SCHEMBL30945405 | 0.79 | DYRK2 (0.57) | DYRK2 | |
| SCHEMBL30883978 | 0.79 | DYRK2 (0.57) | DYRK2 | |
| SCHEMBL26448024 | 0.79 | DYRK2 (0.57) | DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113149978-A | Intermediate compound, preparation method and application thereof | 中国药科大学 | 2021-07-23 | — | — | CN | disclosed |
| CN-112390793-B | CDK6/DYRK2 double-target inhibitor and preparation method and application thereof | 中国药科大学 | 2021-04-27 | — | — | CN | disclosed |
| CN-112390793-A | CDK6/DYRK2 double-target inhibitor and preparation method and application thereof | 中国药科大学 | 2021-02-23 | — | — | CN | disclosed |