Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.34 |
| ▸ | KDM5A | P29375 | 1/20 | 0.34 |
| ▸ | JMJD1C | Q15652 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522081 | 0.81 | MAPK1 (0.41) | KDM4EKMT2ATSHRJAK2MAPT | |
| SCHEMBL17514132 | 0.79 | KDM4E (0.45) | KDM4EKMT2ATDP1ALOX15TSHR | |
| SCHEMBL3640606 | 0.74 | PDPK1 (0.43) | KDM4EJAK2PDPK1CYP3A4GAA | |
| SCHEMBL29498562 | 0.71 | JAK2 (0.47) | KDM4EKMT2AJAK2JAK1MAPT | |
| SCHEMBL19994996 | 0.71 | JAK2 (0.47) | KDM4EKMT2AJAK2JAK1MAPT | |
| SCHEMBL4153491 | 0.69 | CA12 (0.49) | KDM4EKMT2AACMSDMGAM | |
| Urea SCHEMBL28025849 | 0.69 | ITK (0.44) | KDM4EPDPK1CYP3A4GAADYRK1A | |
| SCHEMBL7260405 | 0.69 | JAK2 (0.51) | KDM4EKMT2AJAK2RAB9APDPK1 | |
| SCHEMBL1088781 | 0.68 | KDM4E (0.67) | KDM4EKMT2ATDP1ALOX15TSHR | |
| SCHEMBL23272271 | 0.68 | PDPK1 (0.35) | KDM4EJAK2PDPK1CYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108003161-B | Neurotrophic factor tyrosine kinase receptor inhibitors | 正大天晴药业集团股份有限公司 | 2020-10-09 | — | — | CN | disclosed |