Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 1/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | AKT2 | P31751 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22744021 | 0.82 | JAK2 (0.47) | JAK2PDPK1AURKAAURKBTGFBR1 | |
| SCHEMBL29472092 | 0.82 | JAK2 (0.47) | JAK2GSK3AGSK3BPDPK1AURKA | |
| SCHEMBL22716353 | 0.82 | JAK2 (0.47) | JAK2GSK3AGSK3BPDPK1AURKA | |
| SCHEMBL2036225 | 0.81 | MAP4K1 (0.70) | AURKBMAP4K1KDM4EGAAALDH1A1 | |
| SCHEMBL30675639 | 0.74 | AURKB (0.51) | JAK2GSK3AGSK3BPDPK1AURKA | |
| SCHEMBL13329926 | 0.74 | AURKB (0.51) | JAK2GSK3AGSK3BPDPK1AURKA | |
| SCHEMBL3640606 | 0.74 | PDPK1 (0.43) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL19994996 | 0.71 | JAK2 (0.47) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL29498562 | 0.71 | JAK2 (0.47) | JAK2PDPK1KDM4ECYP3A4GAA | |
| SCHEMBL28523916 | 0.69 | KDM4E (0.41) | JAK2PDPK1KDM4ECYP3A4GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003068773-A1 | PYRAZOLOPYRIDINE DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2003-08-21 | — | — | WO | disclosed |