Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 18/20 | 0.47 |
| ▸ | CCND1 | P24385 | 12/20 | 0.47 |
| ▸ | CCND3 | P30281 | 8/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | CCND2 | P30279 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20425411 | 0.87 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL31372001 | 0.87 | CDK4 (0.53) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL22174807 | 0.86 | CDK4 (0.47) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL25091255 | 0.84 | MEN1 (0.48) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL25091286 | 0.84 | MEN1 (0.47) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL19711678 | 0.83 | CDK4 (0.51) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL31106629 | 0.82 | CDK4 (0.54) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL22174941 | 0.82 | CDK4 (0.49) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL22174830 | 0.82 | CDK4 (0.49) | CDK4CCND1CCND3CDK2CCNE1 | |
| SCHEMBL1991171 | 0.82 | CDK4 (0.50) | CDK4CCND1CCND3CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108586356-B | Ribociclib new intermediate and synthetic method for preparing Ribociclib by using same | 杭州科巢生物科技有限公司 | 2021-02-19 | — | — | CN | disclosed |