Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17574711 | 0.80 | MEN1 (0.55) | TSHRNPSR1FBP1MEN1KMT2A | |
| SCHEMBL30599067 | 0.77 | NPSR1 (0.48) | TSHRNPSR1MEN1KMT2AMAPT | |
| SCHEMBL16539947 | 0.72 | RAPGEF4 (0.52) | FBP1MEN1KMT2AL3MBTL1 | |
| SCHEMBL19284321 | 0.69 | NR4A2 (0.50) | TSHRNPSR1RAB9ANPC1MEN1 | |
| Methyl Benzoate SCHEMBL23044121 | 0.69 | TSHR (0.83) | TSHRRAB9ANPC1FBP1SLC6A3 | |
| Methyl Benzoate SCHEMBL28211382 | 0.69 | TSHR (0.83) | TSHRRAB9ANPC1FBP1SLC6A3 | |
| Methyl Benzoate SCHEMBL1332323 | 0.68 | TSHR (1.00) | TSHRRAB9ANPC1SLC6A3MEN1 | |
| Methyl Benzoate SCHEMBL1867855 | 0.68 | TSHR (1.00) | TSHRRAB9ANPC1SLC6A3MEN1 | |
| Methyl Benzoate SCHEMBL7200 | 0.68 | TSHR (1.00) | TSHRRAB9ANPC1SLC6A3MEN1 | |
| Methyl Benzoate SCHEMBL28945661 | 0.68 | TSHR (1.00) | TSHRRAB9ANPC1SLC6A3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112368285-A | Pyrrolotriazine compounds and methods of inhibiting TAM kinase | 希洛斯医药品股份有限公司 | 2021-02-12 | — | — | CN | disclosed |