Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.56 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.56 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526307 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL29855657 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL28524487 | 1.00 | CHRNB2 (0.56) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL24775559 | 0.82 | CHRNB2 (0.52) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL4280772 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL13331169 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL2527089 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL21207110 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL8164565 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4MEN1KMT2A | |
| SCHEMBL433220 | 0.81 | CHRNB2 (0.53) | CHRNB2CHRNA7CHRNA4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |