Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28521336 | 0.92 | CHRM2 (0.49) | CHRM2ACHEADRB2CHRM3HRH3 | |
| SCHEMBL28953805 | 0.89 | CHRM2 (0.67) | CHRM2ACHEOPRD1KCNH2MCHR1 | |
| SCHEMBL768111 | 0.84 | CHRM2 (0.43) | CHRM2ACHEADRB2CHRM3HRH3 | |
| SCHEMBL768818 | 0.83 | CHRM2 (0.42) | CHRM2ACHEADRB2CHRM3HRH3 | |
| SCHEMBL769143 | 0.80 | CHRM2 (0.40) | CHRM2ADRB2CHRM3HRH3OPRD1 | |
| SCHEMBL768953 | 0.80 | HRH3 (0.42) | CHRM2CHRM3HRH3KCNH2 | |
| SCHEMBL768533 | 0.79 | HRH3 (0.41) | CHRM2CHRM3HRH3KCNH2 | |
| SCHEMBL769138 | 0.79 | HRH3 (0.41) | CHRM2CHRM3HRH3KCNH2 | |
| SCHEMBL767767 | 0.79 | HRH3 (0.41) | CHRM2CHRM3HRH3KCNH2 | |
| SCHEMBL768439 | 0.79 | CHRM2 (0.39) | CHRM2ADRB2CHRM3HRH3MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116514704-B | Rafenacin intermediate and preparation method thereof | 北京远大九和药业有限公司 | 2023-09-29 | — | — | CN | disclosed |
| CN-116514704-A | Rafenacin intermediate and preparation method thereof | 北京远大九和药业有限公司 | 2023-08-01 | — | — | CN | disclosed |
| CN-110526859-B | Revinanexin intermediate, preparation method thereof and preparation method of Revinanexin | 山东百诺医药股份有限公司 | 2021-03-12 | — | — | CN | disclosed |