Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.59 |
| ▸ | RAB9A | P51151 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.42 |
| ▸ | TUBB | P07437 | 2/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 2/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 2/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 2/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 2/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28517872 | 0.90 | NPC1 (0.57) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL28518485 | 0.77 | NPC1 (0.47) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL8873874 | 0.77 | NPC1 (0.71) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL10021266 | 0.77 | NPC1 (0.66) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL4564805 | 0.77 | NPC1 (0.66) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL13599919 | 0.75 | AKT1 (0.55) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL4558475 | 0.75 | NPC1 (0.68) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL8873776 | 0.75 | RAB9A (0.76) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL19314576 | 0.75 | NPC1 (0.68) | NPC1RAB9AKDM4EMAPTALDH1A1 | |
| SCHEMBL971875 | 0.75 | NPC1 (1.00) | NPC1RAB9AKDM4EMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108690018-B | Preparation method of imidazo [1,2-a ] pyridine derivative | 郑州大学 | 2021-01-12 | — | — | CN | disclosed |