Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 9/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 1/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.32 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL255478 | 0.80 | DDB1 (0.40) | CNR2DDB1CRBNIRAK4JAK1 | |
| SCHEMBL24852547 | 0.76 | IRAK4 (0.33) | IRAK4PIK3CDNTRK1FLT3IRAK1 | |
| SCHEMBL25882659 | 0.76 | ACHE (0.43) | CNR2DDB1CRBNIRAK4JAK2 | |
| SCHEMBL24797625 | 0.76 | LRRK2 (0.40) | CNR2IRAK4JAK2JAK1TYK2 | |
| SCHEMBL26688281 | 0.76 | KHK (0.35) | CNR2DDB1CRBNIRAK4FLT3 | |
| SCHEMBL27064153 | 0.75 | OGA (0.33) | IRAK4CLK2LRRK2OGA | |
| SCHEMBL25690863 | 0.75 | ACHE (0.33) | OGA | |
| Hydrochloric Acid SCHEMBL28522809 | 0.74 | IRAK4 (0.39) | DDB1CRBNIRAK4FLT3OGA | |
| Hydrochloric Acid SCHEMBL28522807 | 0.74 | IRAK4 (0.39) | DDB1CRBNIRAK4FLT3OGA | |
| Hydrochloric Acid SCHEMBL28908771 | 0.74 | IRAK4 (0.39) | DDB1CRBNIRAK4FLT3OGA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112218865-B | Pteridinone compounds and uses thereof | 沃泰克斯药物股份有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-112218865-A | Pteridinone compounds and uses thereof | 沃泰克斯药物股份有限公司 | 2021-01-12 | — | — | CN | disclosed |