Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.55 |
| ▸ | PKM | P14618 | 6/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 5/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1699931 | 1.00 | MAPT (0.55) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL1808362 | 1.00 | MAPT (0.55) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL24774848 | 0.94 | MAPT (0.56) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL28532283 | 0.92 | MAPT (0.50) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL28532282 | 0.92 | MAPT (0.50) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL31525120 | 0.92 | MAPT (0.50) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| Trifluoroacetic Acid SCHEMBL28527989 | 0.86 | MAPT (0.49) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL1700417 | 0.85 | MAPT (0.58) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL28527992 | 0.85 | MAPT (0.58) | MAPTPKMPOLBSMN1; SMN2TDP1 | |
| SCHEMBL29855753 | 0.85 | MAPT (0.58) | MAPTPKMPOLBSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |