Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.58 |
| ▸ | PKM | P14618 | 5/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 4/20 | 0.43 |
| ▸ | BCL2L1 | Q07817 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1700417 | 1.00 | MAPT (0.58) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1700419 | 1.00 | MAPT (0.58) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL29855753 | 1.00 | MAPT (0.58) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL28682231 | 0.93 | KMT2A (0.54) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1700798 | 0.92 | KMT2A (0.56) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1701560 | 0.92 | KMT2A (0.56) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1700801 | 0.92 | KMT2A (0.56) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1808362 | 0.85 | MAPT (0.55) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL1699931 | 0.85 | MAPT (0.55) | MAPTPKMKMT2AMEN1POLB | |
| SCHEMBL28525699 | 0.85 | MAPT (0.55) | MAPTPKMKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |