Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23487422 | 0.93 | KDM4E (0.49) | KDM4EATMTAAR1CHRM2CHRM1 | |
| SCHEMBL28527428 | 0.84 | TAAR1 (0.43) | HTR2AKDM4EATMTAAR1CHRM2 | |
| SCHEMBL28527431 | 0.84 | TAAR1 (0.43) | HTR2AKDM4EATMTAAR1CHRM2 | |
| SCHEMBL28537464 | 0.84 | TAAR1 (0.43) | HTR2AKDM4EATMTAAR1CHRM2 | |
| SCHEMBL28526313 | 0.80 | CHRM5 (0.44) | HTR2CTAAR1CYP2D6CHRM2CHRM1 | |
| SCHEMBL24737035 | 0.80 | CHRM5 (0.44) | HTR2CTAAR1CYP2D6CHRM2CHRM1 | |
| SCHEMBL28527595 | 0.78 | CHRM5 (0.43) | HTR2CTAAR1CYP2D6CHRM2CHRM1 | |
| SCHEMBL23323069 | 0.78 | CHRM5 (0.46) | HTR2CTAAR1CYP2D6CHRM2CHRM1 | |
| SCHEMBL22165432 | 0.78 | CHRM5 (0.46) | HTR2CTAAR1CYP2D6CHRM2CHRM1 | |
| SCHEMBL22165430 | 0.78 | CHRM5 (0.46) | HTR2CTAAR1CYP2D6CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |