Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.32 |
| ▸ | HTR2A | P28223 | 2/20 | 0.32 |
| ▸ | HTR2C | P28335 | 2/20 | 0.32 |
| ▸ | HTR2B | P41595 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28534516 | 0.83 | PIK3CB (0.35) | CYP2D6CYP2C9MAPK1CYP2C19PIK3CB | |
| SCHEMBL31525091 | 0.81 | HTR2C (0.41) | HTR2CHTR2BCYP2D6CYP2C9MAPK1 | |
| SCHEMBL28529794 | 0.81 | HTR2C (0.41) | HTR2CHTR2BCYP2D6CYP2C9MAPK1 | |
| SCHEMBL28529792 | 0.81 | HTR2C (0.41) | HTR2CHTR2BCYP2D6CYP2C9MAPK1 | |
| SCHEMBL28528284 | 0.79 | CYP2D6 (0.38) | HRH3CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28528279 | 0.79 | CYP2D6 (0.38) | HRH3CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28909552 | 0.76 | HRH3 (0.41) | HRH3HTR2BCYP2D6CYP2C9MAPK1 | |
| SCHEMBL28909558 | 0.76 | HRH3 (0.41) | HRH3HTR2BCYP2D6CYP2C9MAPK1 | |
| SCHEMBL24775580 | 0.75 | HRH3 (0.38) | HRH3CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28532862 | 0.70 | MAPT (0.41) | CYP2D6CYP2C9MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |