Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.31 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.31 |
| ▸ | BCL2 | P10415 | 1/20 | 0.30 |
| ▸ | MASP2 | O00187 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | PRCP | P42785 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28526304 | 0.83 | HRH3 (0.32) | PIK3CBCYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28529794 | 0.79 | HTR2C (0.41) | CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28529792 | 0.79 | HTR2C (0.41) | CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL31525091 | 0.79 | HTR2C (0.41) | CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28528279 | 0.75 | CYP2D6 (0.38) | CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28528284 | 0.75 | CYP2D6 (0.38) | CYP2D6CYP2C9MAPK1CYP2C19 | |
| SCHEMBL28532862 | 0.73 | MAPT (0.41) | CYP2D6CYP2C9MAPK1CYP2C19FFAR1 | |
| SCHEMBL29139935 | 0.73 | SIGMAR1 (0.44) | CYP2D6CYP2C9CYP2C19BCL2 | |
| SCHEMBL28522991 | 0.72 | RBP4 (0.41) | CYP2D6CYP2C9MAPK1CYP2C19POLB | |
| SCHEMBL28909558 | 0.72 | HRH3 (0.41) | CYP2D6CYP2C9MAPK1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117683029-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-03-12 | — | — | CN | disclosed |
| CN-117430601-A | Bcl-2 inhibitors | 百济神州有限公司 | 2024-01-23 | — | — | CN | disclosed |
| CN-112437772-B | Bcl-2 inhibitors | 百济神州有限公司 | 2023-11-21 | — | — | CN | disclosed |
| CN-112437772-A | Bcl-2 inhibitors | 百济神州有限公司 | 2021-03-02 | — | — | CN | disclosed |