SCHEMBL28526384

SCHEMBL28526384

N#CCN1C=Cc2ccccc2C1

nearest known ligand 0.45

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 1/20 0.45
CA1 P00915 2/20 0.38
CA2 P00918 2/20 0.38
PARP1 P09874 1/20 0.31
HSD17B3 P37058 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25435570 0.77 HDAC3 (0.51) HDAC3CA1CA2PARP1HSD17B3
SCHEMBL10489558 0.77 HDAC3 (0.48) HDAC3CA1CA2PARP1HSD17B3
SCHEMBL28241677 0.77 HDAC3 (0.48) HDAC3CA1CA2PARP1HSD17B3
SCHEMBL1128054 0.77 HDAC3 (0.48) HDAC3PARP1HSD17B3
SCHEMBL14166796 0.77 HDAC3 (0.48) HDAC3CA1CA2PARP1HSD17B3
Iodide SCHEMBL10482528 0.75 HDAC3 (0.47) HDAC3PARP1HSD17B3
Hydrochloric Acid SCHEMBL2111158 0.75 HDAC3 (0.47) HDAC3PARP1HSD17B3
Hydrochloric Acid SCHEMBL507702 0.75 HDAC3 (0.47) HDAC3PARP1HSD17B3
Bromide SCHEMBL4225369 0.75 HDAC3 (0.47) HDAC3PARP1HSD17B3
SCHEMBL14637926 0.75 HDAC3 (0.69) HDAC3PARP1HSD17B3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112174949-A Quinolizinone compound and preparation method thereof 北京师范大学 2021-01-05 CN disclosed