SCHEMBL28526464

SCHEMBL28526464

COC(=O)[C@]1(O)Cc2cc(Br)ccc2C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA4 P22748 1/20 0.41
CA7 P43166 1/20 0.41
CA9 Q16790 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
TDP2 O95551 2/20 0.38
SRD5A1 P18405 2/20 0.37
SRD5A2 P31213 1/20 0.37
METAP1 P53582 2/20 0.36
PARP10 Q53GL7 1/20 0.35
PARP11 Q9NR21 1/20 0.35
KDM4E B2RXH2 1/20 0.34
POLB P06746 1/20 0.34
MAPT P10636 1/20 0.34
SDCBP O00560 1/20 0.34
SDC2 P34741 1/20 0.34
BRD4 O60885 1/20 0.33
NPSR1 Q6W5P4 1/20 0.33
ALDH1A1 P00352 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28534753 1.00 CA1 (0.41) CA1CA2CA4CA7CA9
SCHEMBL28532993 0.89 CA1 (0.41) CA1CA2CA4CA7CA9
SCHEMBL28547714 0.89 CA1 (0.41) CA1CA2CA4CA7CA9
SCHEMBL28600522 0.84 CA1 (0.42) CA1CA2CA4CA7CA9
SCHEMBL1875543 0.84 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2METAP1SDCBP
SCHEMBL30293721 0.84 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2METAP1SDCBP
SCHEMBL29476750 0.84 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2METAP1SDCBP
SCHEMBL1874449 0.84 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2METAP1SDCBP
SCHEMBL29476749 0.84 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2METAP1SDCBP
SCHEMBL29940608 0.84 SMN1; SMN2 (0.42) SMN1; SMN2SRD5A1SRD5A2METAP1SDCBP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114082446-B Chiral zirconium catalyst for preparing chiral alpha-hydroxy-beta-keto ester compound and preparation method thereof 南开沧州渤海新区绿色化工研究有限公司 2023-12-22 CN disclosed
CN-114082446-A Chiral zirconium catalyst for preparing chiral alpha-hydroxy-beta-keto ester compound and preparation method thereof 南开沧州渤海新区绿色化工研究有限公司 2022-02-25 CN disclosed
CN-108516937-B Method for preparing chiral alpha-hydroxy-beta-keto ester compound by visible light-initiated aerobic Salan-copper catalyst 大连理工大学 2021-03-26 CN disclosed