SCHEMBL28547714

SCHEMBL28547714

COC(=O)C1(O)Cc2ccc(Br)cc2C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA1 P00915 2/20 0.41
CA2 P00918 2/20 0.41
CA7 P43166 2/20 0.41
CA9 Q16790 2/20 0.41
CA4 P22748 1/20 0.41
TDP1 Q9NUW8 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
LMNA P02545 1/20 0.37
BACE1 P56817 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSP90AA1 P07900 1/20 0.35
NPSR1 Q6W5P4 3/20 0.35
TDP2 O95551 1/20 0.35
PARP1 P09874 1/20 0.35
PARP10 Q53GL7 1/20 0.35
KDM4E B2RXH2 2/20 0.34
MAPT P10636 2/20 0.34
TGM2 P21980 1/20 0.34
CES1 P23141 1/20 0.34
MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28532993 1.00 CA1 (0.41) CA1CA2CA7CA9CA4
SCHEMBL28526464 0.89 CA1 (0.41) CA1CA2CA7CA9CA4
SCHEMBL28534753 0.89 CA1 (0.41) CA1CA2CA7CA9CA4
SCHEMBL28055447 0.84 CA1 (0.42) CA1CA2CA7CA9CA4
SCHEMBL28055448 0.84 CA1 (0.42) CA1CA2CA7CA9CA4
SCHEMBL28600049 0.83 CA1 (0.41) CA1CA2CA7CA9LMNA
SCHEMBL21954409 0.83 SMN1; SMN2 (0.47) CA1CA2CA7CA9CA4
SCHEMBL28596778 0.83 SMN1; SMN2 (0.38) BACE1SMN1; SMN2PARP1PARP10TGM2
SCHEMBL28608472 0.83 SMN1; SMN2 (0.50) CA1CA2CA7CA9CA4
SCHEMBL12083344 0.81 BACE1 (0.40) TDP1L3MBTL1LMNABACE1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108821976-B Method for catalytic oxidation of indanone-2-formate under micro-reaction condition or conventional reaction condition 吉林大学 2021-07-13 CN disclosed
CN-108516937-B Method for preparing chiral alpha-hydroxy-beta-keto ester compound by visible light-initiated aerobic Salan-copper catalyst 大连理工大学 2021-03-26 CN disclosed