Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | CSF1R | P07333 | 6/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3291506 | 0.90 | CSF1R (0.53) | NPSR1RAB9ACSF1RCCNA2CDK2 | |
| SCHEMBL3291302 | 0.88 | CSF1R (0.49) | NPSR1RAB9ACSF1RTSHRMAPK1 | |
| SCHEMBL28537798 | 0.87 | CSF1R (0.62) | CSF1RMAPT | |
| SCHEMBL28527127 | 0.87 | CSF1R (0.59) | NPSR1RAB9ACSF1RTSHRKDM4E | |
| SCHEMBL3293205 | 0.86 | CSF1R (0.52) | NPSR1RAB9ACSF1RTSHRMAPK1 | |
| SCHEMBL3289961 | 0.86 | POLB (0.49) | NPSR1RAB9ACSF1RTSHRMAPK1 | |
| SCHEMBL3291781 | 0.85 | MAPT (0.49) | NPSR1RAB9ACSF1RTSHRMAPK1 | |
| SCHEMBL3291092 | 0.85 | CSF1R (0.54) | NPSR1RAB9ACSF1RHPGDALDH1A1 | |
| SCHEMBL3292279 | 0.84 | CSF1R (0.53) | NPSR1RAB9ACSF1RHPGDALDH1A1 | |
| SCHEMBL3290631 | 0.83 | CSF1R (0.56) | NPSR1RAB9ACSF1RMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | claimed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |