Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 13/20 | 0.62 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | WEE1 | P30291 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 1/20 | 0.45 |
| ▸ | FLT3 | P36888 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527787 | 0.92 | CSF1R (0.58) | CSF1RNPC1MAPTWEE1AURKA | |
| SCHEMBL3530136 | 0.89 | CSF1R (0.79) | CSF1RWEE1NTRK1KITSRC | |
| SCHEMBL3527207 | 0.88 | CSF1R (0.70) | CSF1RWEE1NTRK1KITSRC | |
| SCHEMBL28526527 | 0.87 | NPSR1 (0.60) | CSF1RMAPT | |
| SCHEMBL4572720 | 0.87 | CSF1R (0.70) | CSF1RWEE1NTRK1KITSRC | |
| SCHEMBL4892224 | 0.86 | CSF1R (0.65) | CSF1RWEE1NTRK1KITSRC | |
| SCHEMBL28527132 | 0.85 | CSF1R (0.64) | CSF1RWEE1GSK3BNTRK1KIT | |
| SCHEMBL3291302 | 0.85 | CSF1R (0.49) | CSF1RNPC1 | |
| SCHEMBL3527452 | 0.85 | CSF1R (0.53) | CSF1RNTRK1KITSRCFLT3 | |
| SCHEMBL3528806 | 0.85 | CSF1R (0.63) | CSF1RNTRK1KITSRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | claimed |
| CN-111848613-B | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2021-09-24 | — | — | CN | disclosed |
| CN-111848613-A | Diaryl pyrimidopyridinone derivative and preparation method and application thereof | 山东大学 | 2020-10-30 | — | — | CN | disclosed |