Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Morpholine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Morpholine SCHEMBL1242574 | 0.87 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL199472 | 0.87 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Ether SCHEMBL9037782 | 0.87 | MEN1 (0.55) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL10949531 | 0.85 | MEN1 (0.48) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Ether SCHEMBL20212029 | 0.85 | MEN1 (0.60) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Ether SCHEMBL8384914 | 0.85 | MEN1 (0.60) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Ether SCHEMBL8483474 | 0.85 | MEN1 (0.60) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Ether SCHEMBL8383317 | 0.85 | MEN1 (0.60) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL11120537 | 0.82 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 | |
| Morpholine SCHEMBL20580623 | 0.82 | MEN1 (0.61) | MEN1KMT2AKDM4EGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100069274-A1 | BOTTLE CONVEYOR LUBRICANT COMPOSITION AND METHOD OF USING THE SAME | JOHNSONDIVERSEY, INC. (US) | 2010-03-18 | — | — | US | disclosed |
| EP-1991647-A1 | BOTTLE CONVEYOR LUBRICANT COMPOSITION AND METHOD OF USING THE SAME | Johnsondiversey, Inc. (US) | 2008-11-19 | — | — | EP | disclosed |
| WO-2007090018-A1 | BOTTLE CONVEYOR LUBRICANT COMPOSITION AND METHOD OF USING THE SAME | JOHNSONDIVERSEY, INC. (US) | 2007-08-09 | — | — | WO | disclosed |